Document Type

Article

Publication Date

4-2012

Publication Title

Ultrasound in Medicine & Biology

Abstract

Effective real-time monitoring of high-intensity focused ultrasound (HIFU) ablation is important for application of HIFU technology in interventional electrophysiology. This study investigated rapid, high-frequency M-mode ultrasound imaging for monitoring spatiotemporal changes during HIFU application. HIFU (4.33 MHz, 1 kHz PRF, 50% duty cycle, 1 s, 2600 – 6100 W/cm2 ) was applied to ex-vivo porcine cardiac tissue specimens with a confocally and perpendicularly aligned high-frequency imaging system (Visualsonics Vevo 770, 55 MHz center frequency). Radiofrequency (RF) data from M-mode imaging (1 kHz PRF, 2 s × 7 mm) was acquired before, during, and after HIFU treatment (n = 12). Among several strategies, the temporal maximum integrated backscatter with a threshold of +12 dB change showed the best results for identifying final lesion width (receiver-operating characteristic curve area 0.91 ± 0.04, accuracy 85 ± 8%, as compared to macroscopic images of lesions). A criterion based on a line-to-line decorrelation coefficient is proposed for identification of transient gas bodies.

Volume

38

Issue

4

First Page

626

Last Page

641

DOI

10.1016/j.ultrasmedbio.2012.01.004

ISSN

0301-5629

Comments

This work was supported by funding from National Institutes of Health (grant R01 EB008999 to C.X. Deng) and the University of Michigan.

This is the Preprint of an article published in Ultrasound in Medicine & Biology, volume 38, issue 4, 2012. Version of record is available at this link from Elsevier.

Rights Statement

© 2012 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved.

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