Title
Characterization of the Pancreas in Vivo Using EUS Spectrum Analysis with Electronic Array Echoendoscopes
Document Type
Article
Publication Date
4-2012
Publication Title
Gastrointestinal Endoscopy
Abstract
Background
Spectral analysis of the radiofrequency (RF) signals that underlie grayscale EUS images has been used to provide quantitative, objective information about tissue histology.
Objective
Our purpose was to validate RF spectral analysis as a method to distinguish between chronic pancreatitis (CP) and pancreatic cancer (PC).
Design and Setting
A prospective study of eligible patients was conducted to analyze the RF data obtained by using electronic array echoendoscopes.
Patients
Pancreatic images were obtained by using electronic array echoendoscopes from 41 patients in a prospective study, including 15 patients with PC, 15 with CP, and 11 with a normal pancreas.
Main Outcome Measurements
Midband fit, slope, intercept, correlation coefficient, and root mean square deviation from a linear regression of the calibrated power spectra were determined and compared among the groups.
Results
Statistical analysis showed that significant differences were observable between groups for mean midband fit, intercept, and root mean square deviation (t test, P < .05). Discriminant analysis of these parameters was then performed to classify the data. For CP (n = 15) versus PC (n = 15), the same parameters provided 83% accuracy and an area under the curve of 0.83.
Limitations
Moderate sample size and spatial averaging inherent in the technique.
Conclusions
This study shows that mean spectral parameters of the backscattered signals obtained by using electronic array echoendoscopes can provide a noninvasive method to quantitatively discriminate between CP and PC.
Volume
75
Issue
6
First Page
1175
Last Page
1183
DOI
10.1016/j.gie.2012.01.039
ISSN
1097-6779
Rights Statement
Copyright © 2012 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
Recommended Citation
Kumon, Ronald; Repaka, Aparna; Atkinson, Matthew; Faulx, Ashley L.; Wong, Richard C.K.; Isenberg, Gerard A.; Hsiao, Yi-Sing; Gudur, Madhu Sudhan Reddy; Deng, Cheri X.; and Chak, Amitabh, "Characterization of the Pancreas in Vivo Using EUS Spectrum Analysis with Electronic Array Echoendoscopes" (2012). Physics Publications. 29.
https://digitalcommons.kettering.edu/physics_facultypubs/29
