Title

Tomographic Reconstruction of Tissue Properties and Temperature Increase for High-Intensity Focused Ultrasound Applications

Document Type

Article

Publication Date

10-1-2013

Publication Title

Ultrasound in medicine & biology

Abstract

The acoustic and thermal properties as well as the temperature change within a tissue volume during high-intensity focused ultrasound ablation are critically important for treatment planning and monitoring. Described in this article is a tomographic reconstruction method used to determine the tissue properties and increase in temperature in a 3-D volume. On the basis of the iterative finite-element solution to the bioheat equation coupled with Tikhonov regularization techniques, our reconstruction algorithm solves the inverse problem of bioheat transfer and uses the time-dependent temperature measured on a tissue surface to obtain the acoustic absorption coefficient, thermal diffusivity and temperature increase within the subsurface volume. Numerical simulations were performed to validate the reconstruction algorithm. The method was initially conducted in ex vivo experiments in which time-dependent temperature on a tissue surface was measured using high-resolution, non-invasive infrared thermography.

Volume

39

Issue

10

First Page

1760

Last Page

1770

DOI

10.1016/j.ultrasmedbio.2013.04.009

ISSN

1879-291X

Rights Statement

© 2013 Pergamon Press, all rights reserved

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