Document Type
Patent
Publication Date
10-2-2012
Abstract
A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a function of time to prevent entrainment. The AMPWM signal is presented to a subject via a plurality of neurostimulation delivery modes for therapeutic use.
Patent Number
Patent Number:US 8,280,502 B2, Australia Patent Number: 2003210835, PCT/US2003/03316
Rights
Assignee: Cerephex Corporation
Recommended Citation
Hargrove, Jeffrey; Stokes, Theodore; and Esty, Mary L., "Method and Apparatus for Utilizing Amplitude-Modulated Pulse-Width Modulation Signals for Neurostimulation and Treatment of Neurological Disorders Using Electrical Stimulation" (2012). Mechanical Engineering Patents. 3.
https://digitalcommons.kettering.edu/mech_eng_patents/3
Included in
Bioelectrical and Neuroengineering Commons, Biomedical Devices and Instrumentation Commons
