Title
Synthesis and biological evaluation of novel taxane terpenoids
Document Type
Presentation
Publication Date
3-29-2004
Publication Title
American Chemical Society
Conference Name
The 227th ACS National Meeting
Abstract
Paclitaxel, a diterpene natural product from the Pacific Yew tree, Taxus brevifolia, has emerged as a promising chemotherapeutic agent for treating solid tumors. The taxane family is one of the most challenging synthetic targets due to their unique carbon skeleton. We have used a powerful methodology based on [2+2] photocycloaddition of double bonds to excited phenylketones to synthesize the 8-membered taxane B rings. The methodology allows the synthesis of taxanes with variety of substituents. We have tested the biological activity of these taxanes for microtubule polymerization/ depolymerization. The results of the synthetic efforts and biological assays will be presented.
Rights Statement
American Chemical Society
Recommended Citation
Gasiorowski, Stephanie; Tischler, Jessica L.; and Zand, Ali R., "Synthesis and biological evaluation of novel taxane terpenoids" (2004). Chemistry & Biochemistry Presentations And Conference Materials. 4.
https://digitalcommons.kettering.edu/chem_biochem_conference/4
