Age Affecting Control in Biological Systems

Document Type

Conference Proceeding

Publication Date


Publication Title

55th Session of the International Statistical Institute

Conference Name

55th Session of the International Statistical Institute, Sydney, Australia


Biological systems can be treated similarly as the devices constructed to perform some preset functions considered in reliability. They perform their functions in the presence of a great number of random factors which may disturb the normal operations. In terms of reliability, keeping most of the biological objects under control is maintenance. The malfunction of some level of the bio-system is equivalent to a failure in the technical device. The applied cure in the bio-system corresponds to the respective repair in reliability. Some medications may make the biological object younger; other may make it older, or not deteriorate its current age. Such kind of "maintenance" has some analogous models in reliability repairs. We use it to incorporate some results of ours and other reliability and bio-modeling with the quantitative studies of the aging and resistance of bio-systems to environmental stress factors. We call as "calendar age" the age of a bio-object which does not use medication, or uses it without age improvement, or deterioration. All bio-objects that use medication of same strength and direction of effect have "virtual age". And we illustrate our general result on the example of the Gompertz law of mortality, and explain the relations of the longevity, mechanism of aging and age affecting control. Numeric and graphical examples are provided.


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© 2005 ISI

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